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MMP-17

CAT: 0209-101-M714Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M714Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage and is known to be expressed in brain, leukocytes, colon, ovary testis and breast cancer as well as in many transformed and non-transformed cell types. The protein exists in two isoforms: a GPI-anchored form and a second secreted form.
Synonyms
Matrix metalloproteinase-17; Membrane-type matrix metalloproteinase 4, Membrane-type-4 matrix metalloproteinase
NCBI Gene ID
4326
UniProt
Q9ULZ9
Accession Number
NP_057239.4
Accession Number mRNA
NM_016155.4
Chromosomal Location
12q24.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-17
Clone
(#12N24)
Applications
ELISA, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
ELISA: 1:1000-2000.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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