MMP-2

• Description:

  Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids) .

• Synonyms:

  MMP2; CLG4; MONA; CLG4A; TBE-1; MMP-II

• NCBI Gene ID:

  4313

• UniProt:

  P08253

• Accession Number:

  NP_004521.1

• Accession Number mRNA:

  NM_004530

• Chromosomal Location:

  16q13-q21

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant Human MMP-2

• Clone:

  Rabbit IgG

• Applications:

  ELISA, WB

• Purification Method:

  Antigen-affinity purified

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  Water

• Host or Source:

  Rabbit