LEC/NCC-4 (CCL16)

• Description:

  LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL16; LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16

• NCBI Gene ID:

  6360

• UniProt:

  O15467

• Accession Number:

  NP_004581.1

• Accession Number mRNA:

  NM_004590.2

• Chromosomal Location:

  17q11.2

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human, Bacteria

• Sequence:

  QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKALNCHLP AIIFVTKRNR EVCTNPNDDW VQEYIKDPNL PLLPTRNLST VKIITAKNGQ PQLLNSQ

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract total human monocytes using a concentration range of 10-100 ng/ml.

• Length:

  97

• Form:

  Lyophilized

• Molecular Weight:

  11.2 kDa

• Host or Source:

  E. coli