MCP-4 (CCL13)

• Description :

  The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-2 is an 8.6 kDa protein containing 75 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms :

  CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13

• NCBI Gene ID :

  6357

• UniProt :

  Q99616

• Accession Number :

  NP_005399

• Accession Number mRNA :

  NM_005408

• Chromosomal Location :

  17q11.2

• Reactivity :

  Human

• Cross Reactivity :

  Monkey, Mouse, Human, Leech

• Sequence :

  QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human monocytes using a concentration of 10.0-100.0 ng/ml.

• Length :

  75

• Form :

  Lyophilized

• Molecular Weight :

  8.6 kDa

• Host or Source :

  E. coli