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Integrin beta 2 (CD18)

CAT: 0209-101-M523Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M523Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM) . Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Synonyms
ITGB2; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
NCBI Gene ID
3689
UniProt
P05107
Accession Number
NP_000202.2
Accession Number mRNA
NM_000211.3
Chromosomal Location
21q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Integrin beta2
Clone
(#4K41)
Applications
WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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