Products for Research Use Only
RegisterLogin

IL-21

CAT: 0209-103-P77Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-103-P77Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Synonyms
Il21
NCBI Gene ID
60505
UniProt
Q9ES17
Accession Number
NP_068554.1
Accession Number mRNA
NM_021782
Chromosomal Location
3 B; 3
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse IL-21
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

Related Products

CatalogName
500-003-L1000FGF-21
M10-047-L100FGF-21
100-337-L500FGF-21
M10-047-1000FGF-21
500-003FGF-21
M10-047FGF-21
M10-047-L1000FGF-21
M10-047-L500FGF-21
100-337-L1000FGF-21
100-337FGF-21

Alternative Products

CatalogName
320164-01IL-21
228232Interleukin-21 (IL-21)
I8442-01BInterleukin 21 (IL-21)
MBS630074-01Interleukin 21, IN (IL-21 IN)
048517IL-21 (Lilly patent IL-21) discontinued
I8442-01B-APCInterleukin 21 (IL-21) (APC)
I8442-06-01Interleukin 21, CT (IL-21)
MBS6483241-01Interleukin 21 (IL-21) (HRP)
GTR19319360-01Interleukin-21 (IL-21), Human
RC212-32IL-21, Interleukin-21, human

Popular Products