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IL-20

CAT: 209-100-230SSize: 2 µgDry Ice: NoHazardous: No
2 µgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-alpha and type II IL-20R-beta. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.
Synonyms
IL20; IL-20; IL10D; ZCYTO10
NCBI Gene ID
50604
UniProt
Q9NYY1
Accession Number
NP_061194.2
Accession Number mRNA
NM_018724
Chromosomal Location
1q32
Reactivity
Human
Cross Reactivity
Human
Sequence
MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to activate STAT following receptor ligand interaction.
Length
153
Form
Lyophilized
Molecular Weight
35.2 kDa
Host or Source
E. coli

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