IL-17A Recombinant Protein

IL-17A Recombinant Protein

• Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
• Synonyms: IL-17, CTLA-8
• CAS Number: 9000-83-3
• NCBI Gene ID: 16171
• UniProt: Q62386
• Accession Number: NP_034682.1
• Accession Number mRNA: NM_010552.3
• Gene Location: 1; 1 A
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Rat, Mouse, Human
• Sequence: AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
• Detection Range: Measured by its ability to induce IL-6 production by NIH 3T3 cells.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 133
• Form: Lyophilized
• Molecular Weight: 30 kDa
• Shipping Conditions: Room Temperature