Rabbit Anti-Human IL-17A Polyclonal Antibody

Rabbit Anti-Human IL-17A Polyclonal Antibody

• Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
• Synonyms: IL17A; IL17; CTLA8; IL-17; IL-17A
• CAS Number: 9007-83-4
• NCBI Gene ID: 3605
• UniProt: Q16552
• Accession Number: NP_002181.1
• Accession Number mRNA: NM_002190.2
• Gene Location: 6p12
• Host: Rabbit
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Recombinant Human IL-17A
• Clone: Rabbit IgG
• Validated Applications: ELISA, WB, N
• Purification Method: Antigen-affinity purified
• Form: Lyophilized from PBS
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.