Recombinant Human Interleukin-17A/IL-17A Protein

• Background:

  Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha; it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis; and produced by rheumatoid arthritis synovium. It increases IL-6 production; induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

• Abbreviation:

  Interleukin-17A; IL-17A

• Synonyms:

  Cytotoxic T-lymphocyte-associated antigen; IL17A; CTLA-8; CTLA8; IL-17; IL-17A; IL17; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA 8; CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) ; Interleukin 17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003

• UniProt:

  Q16552

• Accession Number:

  Q16552

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Ile20-Ala155

• Applications:

  Cell culture

• Field of Research:

  Cancer; immunology

• Endotoxin:

  < 0.01 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 98 % as determined by reducing SDS-PAGE.

• Bioactivity:

  50

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  16.5 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Human