Rabbit Anti-Mouse IL-17A Polyclonal Antibody

Rabbit Anti-Mouse IL-17A Polyclonal Antibody

• Description: The antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor.
• Synonyms: Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A
• CAS Number: 9007-83-4
• NCBI Gene ID: 16171
• UniProt: Q62386
• Accession Number: NP_034682.1
• Accession Number mRNA: NM_010552.3
• Gene Location: 1; 1 A
• Host: Rabbit
• Origin Species: Mouse
• Species Reactivity: Mouse
• Target Antigen: Recombinant Mouse IL-17A
• Clone: Rabbit IgG
• Validated Applications: ELISA, WB
• Purification Method: Antigen-affinity purified
• Form: Lyophilized from PBS
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.