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IL-13

CAT: 0209-M10-071SSize: 2 µgDry Ice: NoHazardous: No
CAT#:0209-M10-071SSize:2 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
Synonyms
Il13; Il-13
NCBI Gene ID
16163
UniProt
P20109
Accession Number
NP_032381.1
Accession Number mRNA
NM_008355
Chromosomal Location
11 B1.3; 11 29.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 105 units/mg.
Length
111
Form
Lyophilized
Buffer
10 mM sodium citrate pH 4.0
Molecular Weight
12.3 kDa
Host or Source
E. coli

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