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MMP-13

CAT: 0209-101-M115Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M115Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP13 (Collagenase-3) has been demonstrated to degrade a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X and XIV, gelatin, aggrecan, perlecan and fibronectin. MMP-13 is distinguished from the other human collagenases by its effecient degradation of type II collagen. MMP13 is expressed by fibroblasts, chrondrocytes and squamous epithelial cells. Structurally, MMP-13 may be divided into several distinct domains; a prodomain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexinlike) domain.
Synonyms
MMP13; CLG3; MANDP1
NCBI Gene ID
4322
UniProt
P45452
Accession Number
NP_002418.1
Accession Number mRNA
NM_002427.3
Chromosomal Location
11q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-13
Clone
(#12E10)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: Use at 1:400-1000; IHC: 1:50-200
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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