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IL-11

CAT: 0209-100-050SSize: 2 µgDry Ice: NoHazardous: No
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CAT#:0209-100-050SSize:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.
Synonyms
IL11; AGIF; IL-11
NCBI Gene ID
3589
UniProt
P20809
Accession Number
NP_000632.1
Accession Number mRNA
NM_000641
Chromosomal Location
19q13.3-q13.4
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human, Bacteria, Virus
Sequence
MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Length
179
Form
Lyophilized
Molecular Weight
19.1 kDa
Host or Source
E. coli

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