GDF-11

CAT: 0209-100-181-L1000Size: 2x 500 µgDry Ice: NoHazardous: No
CAT#:0209-100-181-L1000Size:2x 500 µg
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Description
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.
Synonyms
GDF11; BMP11; BMP-11
NCBI Gene ID
10220
UniProt
O95390
Accession Number
NP_005802
Accession Number mRNA
NM_005811
Chromosomal Location
12q13.2
Reactivity
Human/Mouse/Rat
Cross Reactivity
Mouse
Sequence
NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml.
Length
109
Form
Lyophilized
Molecular Weight
25 kDa
Host or Source
E. coli

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