IL-1 alpha

• Description:

  IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

• Synonyms:

  IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA

• NCBI Gene ID:

  3552

• UniProt:

  P01583

• Accession Number:

  NP_000566.3

• Accession Number mRNA:

  NM_000575

• Chromosomal Location:

  2q14

• Reactivity:

  Human

• Cross Reactivity:

  Cow, Monkey, Mouse, Human, Frog, Pig

• Sequence:

  SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.

• Length:

  159

• Form:

  Lyophilized

• Molecular Weight:

  18 kDa

• Host or Source:

  E. coli