IL-1 alpha Recombinant Protein

IL-1 alpha Recombinant Protein

• Description: IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
• Synonyms: IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA
• CAS Number: 9000-83-3
• NCBI Gene ID: 3552
• UniProt: P01583
• Accession Number: NP_000566.3
• Accession Number mRNA: NM_000575
• Gene Location: 2q14
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Cow, Monkey, Mouse, Human, Frog, Pig
• Sequence: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
• Detection Range: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 159
• Form: Lyophilized
• Molecular Weight: 18 kDa
• Shipping Conditions: Room Temperature