IFN lambda1 (IL-29)

• Description :

  IFN lambda-1, -2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defense similar but distinct than the type I interferons (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77) . Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.

• Synonyms :

  IL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B

• NCBI Gene ID :

  282618

• UniProt :

  Q8IU54

• Accession Number :

  NP_742152.1

• Accession Number mRNA :

  NM_172140.1

• Chromosomal Location :

  19q13.13

• Reactivity :

  Human

• Cross Reactivity :

  Human, Monkey

• Sequence :

  PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.

• Length :

  178

• Form :

  Lyophilized

• Molecular Weight :

  19.8 kDa

• Host or Source :

  E. coli