IFN gamma Recombinant Protein

IFN gamma Recombinant Protein

• Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
• Synonyms: Ifng; Ifg; IFN-g
• CAS Number: 9000-83-3
• NCBI Gene ID: 15978
• UniProt: P01580
• Accession Number: NP_032363
• Accession Number mRNA: NM_008337
• Gene Location: 10 D2; 10 67.0 cM
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Rabbit, Rat, Mouse, Human, Cow
• Sequence: MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC
• Detection Range: Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 134
• Form: Lyophilized
• Molecular Weight: 15.6 kDa
• Shipping Conditions: Room Temperature