IFN gamma Recombinant Protein

IFN gamma Recombinant Protein

• Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant rat IFN-γ is a 15.6 kDa protein containing 135 amino acid residues.
• Synonyms: Ifng; IFNG2
• CAS Number: 9000-83-3
• NCBI Gene ID: 25712
• UniProt: P01581
• Accession Number: NP_620235.1
• Accession Number mRNA: NM_138880.2
• Gene Location: 7q22
• Host: E. coli
• Origin Species: Rat
• Species Reactivity: Mouse, Rat, Human
• Sequence: MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC
• Detection Range: The ED50 as determined by a cytopathic affect inhibition assay with murine L929 cells challenged with EMC virus was ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 135
• Form: Lyophilized
• Molecular Weight: 15.6 kDa
• Shipping Conditions: Room Temperature