RELM beta

• Description:

  RELMβ (Resistin-like molecule β/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003) ) . Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMβ. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa, consisting of two 83 amino acid residue chains.

• Synonyms:

  Retnlb; Xcp3; Fizz2; Relmb; RELMbeta; 9030012B21Rik

• NCBI Gene ID:

  57263

• UniProt:

  Q99P86

• Accession Number:

  NP_076370

• Accession Number mRNA:

  NM_023881

• Chromosomal Location:

  16 B5; 16 33.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse, Pig, Intestinal Worm, Parasite

• Sequence:

  MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Data not available.

• Length:

  83

• Form:

  Lyophilized

• Molecular Weight:

  18 kDa

• Host or Source:

  E. coli