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GDNF

CAT: 0209-102-P18Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P18Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Synonyms
GDNF; ATF1; ATF2; HSCR3; HFB1-GDNF
NCBI Gene ID
2668
UniProt
P39905
Accession Number
NP_000505.1
Accession Number mRNA
NM_000514
Chromosomal Location
5p13.1-p12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human GDNF
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

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