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GDNF

CAT: 0209-101-M437Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M437Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glial cell-derived neurotrophic factor, also known as GDNF is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung's disease. The most prominent feature of GDNF is its ability to support the survival of dopaminergic and motorneurons. These neuronal populations die in the course of Parkinson's disease and amyotrophic lateral sclerosis (ALS) . GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption.
Synonyms
Glial cell line derived neurotrophic factor
NCBI Gene ID
2668
UniProt
P39905
Accession Number
NP_000505.1
Accession Number mRNA
NM_000514.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human GDNF
Clone
(#12F9)
Applications
WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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