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FGF-18 (Animal Free)

CAT: 0209-100-025S-AFSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-025S-AFSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein.
Synonyms
FGF18; ZFGF5; FGF-18
NCBI Gene ID
8817
UniProt
O76093
Accession Number
NP_003853.1
Accession Number mRNA
NM_003862
Chromosomal Location
5q34
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.
Length
173
Form
Lyophilized
Molecular Weight
20.1 kDa
Host or Source
E. coli

UniProtKB · O76093

Fibroblast growth factor 18

FGF18_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O76093
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGF18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FGF-18
EC number
—
Processing
Precursor
Secondary accessions
D3DQL7, Q6UWF1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Disulfide bondGlycoprotein

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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