FGF-18 Recombinant Protein

FGF-18 Recombinant Protein

• Description: FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant E.coli derived human FGF-18 is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from c-terminal truncation of the full length protein.
• Synonyms: FGF18; ZFGF5; FGF-18
• CAS Number: 9000-83-3
• NCBI Gene ID: 8817
• UniProt: O76093
• Accession Number: NP_003853.1
• Accession Number mRNA: NM_003862
• Gene Location: 5q34
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Mouse, Rat, Human
• Sequence: AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR
• Detection Range: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg).
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Length: 173
• Form: Lyophilized
• Molecular Weight: 20.1 kDa
• Shipping Conditions: Room Temperature