FGF-8B (Animal Free)

• Description:

  FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.

• Synonyms:

  FGF8; AIGF; KAL6; FGF-8; HBGF-8

• NCBI Gene ID:

  2253

• UniProt:

  P55075

• Accession Number:

  NP_149355

• Accession Number mRNA:

  NM_033165

• Chromosomal Location:

  10q24

• Reactivity:

  Human/Murine

• Sequence:

  MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 97% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 2.0-4.0 ng/ml.

• Length:

  193

• Form:

  Lyophilized

• Molecular Weight:

  22.4 kDa

• Host or Source:

  E. coli