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FGF-6

CAT: 0209-100-019SSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-019SSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGF-6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.
Synonyms
FGF6; HST2; HBGF-6
NCBI Gene ID
2251
UniProt
P10767
Accession Number
NP_066276
Accession Number mRNA
NM_020996
Chromosomal Location
12p13
Reactivity
Human
Cross Reactivity
Human
Sequence
GTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Length
168
Form
Lyophilized
Buffer
10 mM NaP, pH 7.2 + 50 mM NaCl
Molecular Weight
18.7 kDa
Host or Source
E. coli

UniProtKB · P10767

Fibroblast growth factor 6

FGF6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10767
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGF6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FGF-6
EC number
—
Processing
Precursor
Secondary accessions
Q0VAE1
Protein keywords

Biological process

AngiogenesisDifferentiation

Molecular function

Developmental proteinGrowth factorMitogen

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Disease

Proto-oncogene

Cellular component

Secreted

Domain

Signal

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MBS692129-01Human FGF-6
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BL10626_RRecombinant Human FGF-6
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