CXCR4

CAT: 0209-103-M522Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-103-M522Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXCR4 (short for CXC motif chemokine receptor 4) is a receptor protein of the chemokine receptor family. CXCR4 is common in many cells of the hematopoietic system and is expressed in particular by many stem cells and tumor cells. This receptor is activated by the chemokine CXCL12 and the cytokine macrophage migration inhibitory factor (MIF) . CXCR4 plays a key role in the mobilization and targeted migration of stem cells to their storage (e.g., fetal liver, bone marrow) or their sites of use in organ formation (organogenesis) and organ and wound healing. Pathophysiologically, CXCR4 is involved in tumor growth and metastatic spread as well as inflammatory processes. In addition, CXCR4 is the primary co-receptor for T cell-using (T-tropic) HI viruses.
Synonyms
C-X-C chemokine receptor type 4, CXC-R4; CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor (LESTR), Pre-B-cell-derived chemokine receptor (PB-CKR), Stromal cell-derived factor 1 receptor (SDF-1 receptor)
NCBI Gene ID
12767
UniProt
P70658
Accession Number
NP_034041.2
Accession Number mRNA
NM_009911.3
Reactivity
Anti-Mouse
Target Antigen
Mouse recombinant CXCR4
Clone
(#30L4)
Applications
FC, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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