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Coagulation Factor XI (Light Chain)

CAT: 0209-101-M332Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M332Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coagulation Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with High Molecular Weight Kininogen. Factor XI is converted into active XIa either via the contact phase of blood coagulation or through Thrombin-mediated activation on the platelet surface. The resulting XIa converts Coagulation Factor IX into IXa, which subsequently activates Coagulation Factor X (Xa) . Xa then can mediate Coagulation Factor II/Thrombin activation. Patients with factor XI deficiency are prone to excessive bleeding after hemostatic challenge.
Synonyms
F11; FXI
NCBI Gene ID
2160
UniProt
P03951
Accession Number
NP_000119.1
Accession Number mRNA
NM_000128.3
Chromosomal Location
4q35
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant Coagulation factor XI
Clone
(#7C38)
Applications
WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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MBS6297308-01F11, ID (F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain) (Biotin)
MBS6297316-01F11, ID (F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain) (PE)
MBS6297306-01F11, ID (F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain) (AP)
MBS6297309-01F11, ID (F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain) (FITC)

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