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Coagulation Factor II (Thrombin)

CAT: 0209-101-M330Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M330Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coagulation Factor II/thrombin is an essential component of the coagulation cascade in which it converts fibrinogen to fibrin, activates coagulation factors V, VII, VIII, XIII and forms complexes with protein C and thrombomodulin. It also activates platelets and regulates the behavior of additional cells through protease-activated receptors (PARs) . A plasma serine protease, thrombin is synthesized as a 622 amino acid precursor with a 24 amino acid signal peptide and a 19 residue pro peptide. The mature chain can be further processed into several forms including those designated as alpha-, beta- and gamma-thrombin.
Synonyms
MCFD2; F5F8D; SDNSF; F5F8D2; LMAN1IP
NCBI Gene ID
90411
UniProt
P00734
Accession Number
NP_000497.1
Accession Number mRNA
NM_000506.3
Chromosomal Location
2p21
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant Coagulation factor II
Clone
(#10B23)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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