Coagulation Factor II (Thrombin)

• Description:

  Coagulation Factor II/thrombin is an essential component of the coagulation cascade in which it converts fibrinogen to fibrin, activates coagulation factors V, VII, VIII, XIII and forms complexes with protein C and thrombomodulin. It also activates platelets and regulates the behavior of additional cells through protease-activated receptors (PARs) . A plasma serine protease, thrombin is synthesized as a 622 amino acid precursor with a 24 amino acid signal peptide and a 19 residue pro peptide. The mature chain can be further processed into several forms including those designated as alpha-, beta- and gamma-thrombin.

• Synonyms:

  MCFD2; F5F8D; SDNSF; F5F8D2; LMAN1IP

• NCBI Gene ID:

  90411

• UniProt:

  P00734

• Accession Number:

  NP_000497.1

• Accession Number mRNA:

  NM_000506.3

• Chromosomal Location:

  2p21

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Human recombinant Coagulation factor II

• Clone:

  (#10B23)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2