Cerberus-1

• Description :

  Cerberus 1, also called DAND4, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and COCO/Dante (DAND5) . DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. Cerberus-S, which is generated by proteolysis in Xenopus, is a short version of the molecule and includes the C-terminal cysteine knot domain.

• Synonyms :

  Cer1; Cerl; Cerl1; Cerr1; cer-1

• NCBI Gene ID :

  12622

• UniProt :

  O55233

• Accession Number :

  NP_034017.1

• Accession Number mRNA :

  NM_009887.2

• Chromosomal Location :

  4 C3; 4 42.6 cM

• Reactivity :

  Anti-Mouse

• Cross Reactivity :

  Mouse

• Target Antigen :

  Mouse recombinant Cerberus 1

• Clone :

  (#8K12)

• Applications :

  WB

• Purification Method :

  Protein G/A chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS (sterile)

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Rat

• Isotype :

  IgG2