Cerberus-2 (COCO)

• Description:

  COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and Cerberus (DAND4) . DAN family members contain a cysteine-knot domain that is homologous to that found in other TGF-beta superfamily ligands. BMPs play important roles in tissue morphogenesis and development processes. The human COCO cDNA encodes a 189 amino acid (aa) precursor with a 22 aa signal sequence. COCO has eight Cys residues in the cysteine-knot which places it in the CAN subfamily of BMP antagonists along with the other DAN family proteins. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt-8. In mouse, COCO expression is elevated on the right side of Henson’s node at the early somite stage, in contrast to the left side expression of Nodal (8) . COCO may cooperate with Nodal in gastrulation and embryonic left-right axis formation.

• Synonyms:

  Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, Protein related to DAN and cerberus, GREM2

• NCBI Gene ID:

  64388

• UniProt:

  Q8N907

• Accession Number:

  NP_071914.3

• Accession Number mRNA:

  NM_022469.3

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant Human COCO

• Clone:

  (#5P25)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1