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Cerberus-2 (COCO)

CAT: 0209-101-M851Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M851Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and Cerberus (DAND4) . DAN family members contain a cysteine-knot domain that is homologous to that found in other TGF-beta superfamily ligands. BMPs play important roles in tissue morphogenesis and development processes. The human COCO cDNA encodes a 189 amino acid (aa) precursor with a 22 aa signal sequence. COCO has eight Cys residues in the cysteine-knot which places it in the CAN subfamily of BMP antagonists along with the other DAN family proteins. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt-8. In mouse, COCO expression is elevated on the right side of Henson’s node at the early somite stage, in contrast to the left side expression of Nodal (8) . COCO may cooperate with Nodal in gastrulation and embryonic left-right axis formation.
Synonyms
Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, Protein related to DAN and cerberus, GREM2
NCBI Gene ID
64388
UniProt
Q8N907
Accession Number
NP_071914.3
Accession Number mRNA
NM_022469.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human Cerberus-2 (COCO)
Clone
(#5P68)
Applications
Capture Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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Alternative Products

CatalogName
MBS692583-01Cerberus-2 (COCO)
hAP-5770Sheep Polyclonal anti-Human Cerberus-2 (COCO)
hAP-1200Mouse Monoclonal anti-human Cerberus-2 (COCO)
219681DAND5, NT (COCO, DANTE, CKTSF1B3, DAN Domain Family Member 5, Cerberus-like 2 Protein) discontinued
D1038-08ADAND5 (DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, GREM3, Gremlin-3, SP1)
D1038-08DAND5 (DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1) (Biotin)
MBS692584-01COCO
C24400-01Coco diethanolamide
3356-CC-025Recombinant Mouse COCO
3047-CC-050Recombinant Human COCO

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