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CD105/Endoglin, Antagonistic

CAT: 0209-mT1001m-hSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-mT1001m-hSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endoglin, also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for TGF-beta superfamily ligands. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages.
Synonyms
Endoglin; END; ORW; HHT1; ORW1; CD105
NCBI Gene ID
2022
UniProt
P17813
Accession Number
NP_000109
Accession Number mRNA
NM_000118
Chromosomal Location
9q33-q34.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human endoglin extra-cellular domain
Clone
(#7D11)
Applications
Blocking TGF-beta1 induced threonine/serine phosphorylation of endoglin
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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