CD105/Endoglin

CAT: 0209-102-PA60SSize: 100 µgDry Ice: NoHazardous: No
CAT#:0209-102-PA60SSize:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human Endoglin, the S-Endoglin and L-Endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse Endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human Endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT) . Mice heterozygous for Endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Synonyms
Endoglin; END; ORW; HHT1; ORW1; CD105
NCBI Gene ID
2022
UniProt
P17813
Accession Number
NP_000109
Accession Number mRNA
NM_000118
Chromosomal Location
9q33-q34.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human sCD105/Endoglin (RT #S01-025)
Clone
Rabbit IgG
Applications
WB, E, FC, IF
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 1-5 µg/ml
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

Related Products

CatalogName
101-M287CD102
S01-063-L250CD100, soluble
S01-063SCD100, soluble
S01-063-L500CD100, soluble
S01-063CD100, soluble
S01-063-L100CD100, soluble
S01-063-L1000CD100, soluble
M60-104-L100ICAM-2 / CD102 Protein
M60-196-L100VCAM1 / CD106 Protein (His & hFc Tag)
600-308-L100VCAM-1 / CD106 Protein (His Tag)

Alternative Products

CatalogName
PR27035-01CD105 (Endoglin)
216482Endoglin (CD105)
GT15247Endoglin/CD105
F48291-0.08MLCD105 Antibody / Endoglin
V3341-100UGEndoglin Antibody / CD105
E80902-1CD105 (Endoglin) Antibody
FC15022Endoglin/CD105 Fluorescein
CST 3290SCD105/Endoglin Antibody
GWB-846D80CD105. ENDOGLIN, Antibody
EK0644h.Endoglin/CD105

Popular Products