CD105/Endoglin

• Description :

  CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-ß1 and ß3 with high affinity but not to TGF-ß2.

• Synonyms :

  Endoglin; END; ORW; HHT1; ORW1; CD105

• NCBI Gene ID :

  2022

• UniProt :

  P17813

• Accession Number :

  NP_000109

• Accession Number mRNA :

  NM_000118

• Chromosomal Location :

  9q33-q34.1

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Cell membrane glycoproteins of lymphoblastic leukemia cells

• Clone :

  (#12J11)

• Applications :

  IHC

• Purification Method :

  Protein G/A chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Mouse

• Isotype :

  IgG1