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CD105 Antibody / Endoglin

CAT: 0800-F48291-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F48291-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
P17813
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 380-409 from the human protein was used as the immunogen for this CD105 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CD105 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD105 antibody is available for research use only.
Storage Conditions
Aliquot the CD105 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CD105 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasmic
Image Legend
Western blot analysis of CD105 antibody and mouse heart tissue lysate. Observed molecular weight: 70/90 kDa (monomer, unmodified/glycosylated) ; 140-180 kDa (dimer, unmodified/glycosylated) .

UniProtKB · P17813

Endoglin

EGLN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17813
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ENG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q14248, Q14926, Q5T9C0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisCell adhesion

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix
Product Datasheet
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