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CCL-17 (TARC)

CAT: 0209-103-M323Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M323Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human thymus and activationregulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse CCL17 was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse CCL17 cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse CCL17 is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant CCL17 has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, CCL17 was identified to be a specific functional ligand for CCR4 and CCR8, receptors that are selectively expressed on T cells.
Synonyms
Ccl17; Tarc; Abcd-2; Scya17; Scya17l
NCBI Gene ID
20295
UniProt
Q9WUZ6
Accession Number
NP_035462
Accession Number mRNA
NM_011332
Chromosomal Location
8 C5; 8 45.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse CCL-17
Clone
(#9K49)
Applications
WB, N
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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Alternative Products

CatalogName
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hAP-5708Sheep Polyclonal anti-Human CCL-17 (TARC)
GTR18090039Rat Monoclonal mouse CCL-17 (TARC) Antibody
216189CCL-17 (TARC, Chemokine C-C Motif Ligand 17)
220304TARC, Recombinant, Human (C-C Motif Chemokine 17, Small-Inducible Cytokine A17, Thymus and Activation-Regulated Chemokine, CC Chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E53, MGC138271, MGC138273) discontinued
MBS8532899-01C-C motif chemokine 17/CCL17/TARC
500480TARC, Recombinant, Human (CC Chemokine TARC, Small-Inducible Cytokine A17, C-C Motif Chemokine 17, Chemokine 17, CCL17, ABCD-2, SCYA17, TARC, Thymus and Activation-Regulated Chemokine, CCL17) discontinued
142475Thymus Activation Regulated Chemokine (TARC, ABCD-2, CCL17, SCYA17, TARC, Small Inducible Cytokine Subfamily A (Cys-Cys) Member 17)

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