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Cathepsin B

CAT: 0209-103-M314Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M314Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin B (CTSB) is a papain-family cysteine protease that is normally located in lysosomes, and is a member of a superfamily of structurally similar tissue proteinases having a 25 kDa catalytic unit. Cathepsin B is synthesized as a preproenzyme and the primary pathways for its normal trafficking to the lysosome utilize mannose 6-phosphate receptors (MPRs) . Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Overexpression and altered trafficking of cathepsin B characterize the malignant phenotype of tumor cells, and thus CTSB is suggested as a tumor marker.
Synonyms
Ctsb; CB
NCBI Gene ID
13030
UniProt
P10605
Accession Number
NP_031824
Accession Number mRNA
NM_007798
Chromosomal Location
14 D1; 14 28.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse Cathepsin-B
Clone
(#6C15)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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Alternative Products

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218083-01CTSZ (Cathepsin Z, Cathepsin X, Cathepsin P)
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216172Cathepsin 7 (Cathepsin-7)
216171Cathepsin 6 (Cathepsin-6)
216170Cathepsin 3 (Cathepsin-3)
311158-01Cathepsin Z, cleaved (L62) (CTSZ, Cathepsin Z, Cathepsin P, Cathepsin X)
309394-01CTSK (Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSO, CTSO2)
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