Cathepsin H

• Description:

  Cathepsin H is a lysosomal cysteine protease of the papain family (. It is synthesized as a precursor protein, consisting of a signal peptide (residues 1-20), a propeptide (residues 21-95), a mini chain (residues 96-103), a heavy chain (residues 114-290) and a light chain (residues 291-333) . A truncated form with a 12 amino acid deletion in the signal peptide region is secreted. Cathepsin H is the only known monoaminopeptidase in the papain family. Cathepsin H expression is significantly increased in prostate tumors, sera of asthmatic patients, and mucosa of colorectal cancer patients.

• Synonyms:

  Ctsh; AL022844

• NCBI Gene ID:

  13036

• UniProt:

  P49935

• Accession Number:

  NP_031827

• Accession Number mRNA:

  NM_007801

• Chromosomal Location:

  9 E3. 1; 9 50.0 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant human Cathepsin-H

• Clone:

  (#8J11)

• Applications:

  WB

• Purification Method:

  Protein G/A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2