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Cathepsin A

CAT: 0209-101-M244Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M244Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family. Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with βgalactosidase (βgal) and neuraminidase is essential for βgal stability and neuraminidase activation in the lysosomes. Inherited deficiency of Cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of βgal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal Cathepsin A plays a role in regulation of functions of these molecules. Cathepsin A is synthesized as a singlechain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.
Synonyms
CTSA; GSL; GLB2; NGBE; PPCA; PPGB
NCBI Gene ID
5476
UniProt
P10619
Accession Number
NP_000299
Accession Number mRNA
NM_000308
Chromosomal Location
20q13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Cathepsin-A
Clone
(#14H2)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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