Cathepsin E

CAT: 0209-101-M248Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M248Size:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin E is an intracellular aspartic protease of the pepsin family. Unlike Cathepsin D, another member of the same family and a lysosomal protease with relatively ubiquitous distribution, Cathepsin E is not a lysosomal enzyme and has a limited cell and tissue distribution. However, both Cathepsin D and E play an important role in the degradation of proteins, the generation of bioactive proteins, and antigen processing. Both enzymes are efficient in cleaving Swedish mutant of amyloid precursor protein (APP) at the β site but show almost no reactivity with wildtype APP. Human Cathepsin E is synthesized as a precursor protein, consisting of a signal peptide (aa 1-17), a propeptide (aa 18-53), and a mature chain (aa 54-396) .
Synonyms
CTSE; CATE
NCBI Gene ID
1510
UniProt
P14091
Accession Number
NP_001901
Accession Number mRNA
NM_001910
Chromosomal Location
1q31
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Cathepsin-E
Clone
(#4F50)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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