BD-1 (36aa) Recombinant Protein

BD-1 (36aa) Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues.
• Synonyms: DEFB1; BD1; HBD1; DEFB-1; DEFB101
• CAS Number: 9000-83-3
• NCBI Gene ID: 1672
• UniProt: P60022
• Accession Number: NP_5209.1
• Accession Number mRNA: NM_005218
• Gene Location: 8p23.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Bacteria, Human
• Sequence: DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK
• Detection Range: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 36
• Form: Lyophilized
• Molecular Weight: 3.9 kDa
• Shipping Conditions: Room Temperature