BAFF receptor, soluble Recombinant Protein

BAFF receptor, soluble Recombinant Protein

• Description: BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.
• Synonyms: TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• CAS Number: 9000-83-3
• NCBI Gene ID: 115650
• UniProt: Q96RJ3
• Accession Number: NP_443177
• Accession Number mRNA: NM_052945
• Gene Location: 22q13.1-q13.31
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Mouse
• Sequence: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG
• Detection Range: Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Length: 76
• Form: Lyophilized
• Molecular Weight: 7.7 kDa
• Shipping Conditions: Room Temperature