BAFF Recombinant Protein

BAFF Recombinant Protein

• Description: BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human soluble BAFF is a 153 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.
• Synonyms: TNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
• CAS Number: 9000-83-3
• NCBI Gene ID: 10673
• UniProt: Q9Y275
• Accession Number: NP_006564.1
• Accession Number mRNA: NM_006573.4
• Gene Location: 13q32-q34
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
• Detection Range: Determined by its dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is less than 10 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 153
• Form: Lyophilized
• Buffer: 0.5 x PBS pH 7.5 + 0.5 mM DTT
• Molecular Weight: 17.0 kDa
• Shipping Conditions: Room Temperature