TWEAK receptor, soluble Recombinant Protein

TWEAK receptor, soluble Recombinant Protein

• Description: TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.
• Synonyms: TNFRSF12A; FN14; CD266; TWEAKR
• CAS Number: 9000-83-3
• NCBI Gene ID: 51330
• UniProt: Q9NP84
• Accession Number: NP_057723.1
• Accession Number mRNA: NM_016639.2
• Gene Location: 16p13.3
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
• Detection Range: Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 53
• Form: Lyophilized
• Molecular Weight: 5.6 kDa
• Shipping Conditions: Room Temperature