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Nimustine (hydrochloride)

CAT: 0804-HY-13703A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13703A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine. Nimustine hydrochloride is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine hydrochloride activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].
CAS Number
55661-38-6
Product Name Alternative
ACNU
UNSPSC
12352005
Hazard Statement
H301, H351
Target
AP-1; Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; JNK; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nimustine-hydrochloride.html
Purity
98.22
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O.[H]Cl
Molecular Formula
C9H14Cl2N6O2
Molecular Weight
309.15
Precautions
H301, H351
References & Citations
[1]Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6 (32) :33755-68.|[2]Shimizu F, et al. Effects of combined treatment with nimustine hydrochloride and radiation on solid FM3A tumor in mice. Jpn J Cancer Res. 1987 Jul;78 (7) :756-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched

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