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Nimustine

CAT: 0804-HY-13703Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13703Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].
CAS Number
42471-28-3
UNSPSC
12352005
Target
AP-1; Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; JNK; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nimustine.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O
Molecular Formula
C9H13ClN6O2
Molecular Weight
272.69
References & Citations
[1]Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6 (32) :33755-68.|[2]Shimizu F, et al. Effects of combined treatment with nimustine hydrochloride and radiation on solid FM3A tumor in mice. Jpn J Cancer Res. 1987 Jul;78 (7) :756-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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