Nimustine

• Description :

  Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].

• UNSPSC :

  12352005

• Target :

  AP-1; Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; JNK; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nimustine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O

• Molecular Formula :

  C9H13ClN6O2

• Molecular Weight :

  272.69

• References & Citations :

  [1]Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6 (32) :33755-68.|[2]Shimizu F, et al. Effects of combined treatment with nimustine hydrochloride and radiation on solid FM3A tumor in mice. Jpn J Cancer Res. 1987 Jul;78 (7) :756-62.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [42471-28-3]