NSC-370284

CAT: 0804-HY-122258-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-122258-01Size:5 mg

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Description

NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC) . NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].

CAS Number

116409-29-1

UNSPSC

12352005

Target

STAT; TET Protein

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-370284.html

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(C(N2CCCC2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1

Molecular Formula

C21H25NO6

Molecular Weight

387.43

References & Citations

[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8 (1) :2099.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3; STAT5; TET1

Chemical Information

6-(1-Pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl)-1,3-benzodioxol-5-ol

CAS Number	116409-29-1
PubChem CID	340208
IUPAC Name	6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
Molecular Formula	C21H25NO6
Molecular Weight	387.4
XLogP	3.3
Topological Polar Surface Area	69.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	487

SMILES

COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4

InChI

InChI=1S/C21H25NO6/c1-24-18-8-13(9-19(25-2)21(18)26-3)20(22-6-4-5-7-22)14-10-16-17(11-15(14)23)28-12-27-16/h8-11,20,23H,4-7,12H2,1-3H3

InChIKey

QCXGNLZKUHBIHD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 116409-29-1

CID: 340208

Formula: C21H25NO6

MW: 387.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	387.4
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	387.16818752
Monoisotopic Mass	387.16818752
Topological Polar Surface Area	69.6 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	487
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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