Pomalidomide-C6-COOH

• UNSPSC Description:

  Pomalidomide-C6-COOH is the pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pomalidomide-c6-cooh.html

• Purity:

  98.02

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

• Molecular Weight:

  401.41

• References & Citations:

  [1]Xiaojuan Qu, et al. Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. Eur J Med Chem. 2021.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2225940-50-9