Lofexidine-d4

• Description :

  Lofexidine-d4 is deuterium labeled Lofexidine (hydrochloride) . Lofexidine (hydrochloride) is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2][3].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease; Endocrinology

• Smiles :

  CC(C1=NC([2H])([2H])C([2H])([2H])N1)OC2=C(C=CC=C2Cl)Cl

• Molecular Formula :

  C11H8D4Cl2N2O

• Molecular Weight :

  263.16

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9 (11) :1371-7.|[3]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44 (2) :343-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [78302-26-8]